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Proto-Oncogene Proteins c-kit
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D019009 |
[A protein-tyrosine kinase receptor that is specific for STEM CELL FACTOR. This interaction is crucial for the development of hematopoietic, gonadal, and pigment stem cells. Genetic mutations that disrupt the expression of PROTO-ONCOGENE PROTEINS C-KIT are associated with PIEBALDISM, while overexpression or constitutive activation of the c-kit protein-tyrosine kinase is associated with tumorigenesis.
] |
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Esthesioneuroblastoma, Olfactory
|
C04.557.470.670.590.650.550.150 |
|
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Neuroblastoma
|
C04.557.470.670.590.650.550 |
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Phenylthiourea
|
D010670 |
|
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Galanin
|
D019004 |
[A neuropeptide of 29-30 amino acids depending on the species. Galanin is widely distributed throughout the BRAIN; SPINAL CORD; and INTESTINES. There are various subtypes of GALANIN RECEPTORS implicating roles of galanin in regulating FOOD INTAKE; pain perception; memory; and other neuroendocrine functions.
] |
|
beta-Thromboglobulin
|
D12.776.124.125.050 |
|
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Cystic Fibrosis Transmembrane Conductance Regulator
|
D019005 |
[A chloride channel that regulates secretion in many exocrine tissues. Abnormalities in the CFTR gene have been shown to cause cystic fibrosis. (Hum Genet 1994;93(4):364-8)
] |
|
Phenylurea Compounds
|
D010671 |
[Compounds that include the amino-N-phenylamide structure.
] |
|
Phenytoin
|
D010672 |
[An anticonvulsant that is used to treat a wide variety of seizures. It is also an anti-arrhythmic and a muscle relaxant. The mechanism of therapeutic action is not clear, although several cellular actions have been described including effects on ion channels, active transport, and general membrane stabilization. The mechanism of its muscle relaxant effect appears to involve a reduction in the sensitivity of muscle spindles to stretch. Phenytoin has been proposed for several other therapeutic uses, but its use has been limited by its many adverse effects and interactions with other drugs.
] |
|
Neural Cell Adhesion Molecules
|
D019006 |
[Cell adhesion molecule involved in a diverse range of contact-mediated interactions among neurons, astrocytes, oligodendrocytes, and myotubes. It is widely but transiently expressed in many tissues early in embryogenesis. Four main isoforms exist, including CD56; (CD56 ANTIGEN); but there are many other variants resulting from alternative splicing and post-translational modifications. (From Pigott & Power, The Adhesion Molecule FactsBook, 1993, pp115-119)
] |
|
Hares
|
D034621 |
[Various species of HARES in the genus Lepus, not RABBITS.
, The genus Lepus, in the family Leporidae, order LAGOMORPHA. Hares are born above ground, fully furred, and with their eyes and ears open. In contrast with RABBITS, hares have 24 chromosome pairs.
] |
|
Sesquiterpenes, Guaiane
|
D04.663.500.750 |
|
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Ranolazine
|
D03.383.606.841 |
|
|
Pheochromocytoma
|
D010673 |
[A usually benign, well-encapsulated, lobular, vascular tumor of chromaffin tissue of the ADRENAL MEDULLA or sympathetic paraganglia. The cardinal symptom, reflecting the increased secretion of EPINEPHRINE and NOREPINEPHRINE, is HYPERTENSION, which may be persistent or intermittent. During severe attacks, there may be HEADACHE; SWEATING, palpitation, apprehension, TREMOR; PALLOR or FLUSHING of the face, NAUSEA and VOMITING, pain in the CHEST and ABDOMEN, and paresthesias of the extremities. The incidence of malignancy is as low as 5% but the pathologic distinction between benign and malignant pheochromocytomas is not clear. (Dorland, 27th ed; DeVita Jr et al., Cancer: Principles & Practice of Oncology, 3d ed, p1298)
] |
|
P-Selectin
|
D019007 |
[Cell adhesion molecule and CD antigen that mediates the adhesion of neutrophils and monocytes to activated platelets and endothelial cells.
] |
|
RNA Interference
|
D034622 |
[A gene silencing phenomenon whereby specific dsRNAs (RNA, DOUBLE-STRANDED) trigger the degradation of homologous mRNA (RNA, MESSENGER). The specific dsRNAs are processed into SMALL INTERFERING RNA (siRNA) which serves as a guide for cleavage of the homologous mRNA in the RNA-INDUCED SILENCING COMPLEX. DNA METHYLATION may also be triggered during this process.
, Joint gene silencing of extra copies of genes, such as TRANSGENES, along with the original endogenous gene. Cosuppression is induced by the presence of the extra gene copies via mechanisms that are related to RNA INTERFERENCE.
] |
|
Sparganum
|
B01.050.500.500.736.215.800.810 |
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Stilbestrols
|
D02.455.426.559.389.150.700.725 |
|
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DNA End-Joining Repair
|
G02.111.222.200 |
|
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Forensic Psychology
|
I01.198.780.960 |
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