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amino_acid_substitution
|
SO_0001606 |
|
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spinocerebellar ataxia 21
|
DOID_0050972 |
[An autosomal dominant cerebellar ataxia that is characterized by progressive cerebellar ataxia, cognitive impairment, tremor, bradykinesia and rigidity.] |
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conservative_amino_acid_substitution
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SO_0001607 |
|
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spinocerebellar ataxia 26
|
DOID_0050975 |
[An autosomal dominant cerebellar ataxia that is characterized by slowly progressive ataxia and oculomotor abnormalities, has_material_basis_in mutation in the EEF2 gene.] |
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non_conservative_amino_acid_substitution
|
SO_0001608 |
|
|
spinocerebellar ataxia 25
|
DOID_0050974 |
[An autosomal dominant cerebellar ataxia that is characterized by ataxia and sensory neuropathy, has_material_basis_in repeat CAG expansion on chromosome 2p15-p21.] |
|
spinocerebellar ataxia 28
|
DOID_0050977 |
[An autosomal dominant cerebellar ataxia that is characterized by progressive ataxia, dysarthria, hyperreflexia, ophthalmoparesis, nystagmus and ptosis, and has_material_basis_in mutation in the AFG3L2 gene.] |
|
spinocerebellar ataxia 27A
|
DOID_0050976 |
[An autosomal dominant cerebellar ataxia that is characterized by general cerebellar dysfunction manifest as gait disturbances, ataxia, tremor, dysarthria, and gaze-evoked nystagmus and has_material_basis_in heterozygous mutation in the FGF14 gene on chromosome 13q33. Some patients have heterozygous deletions of chromosome 13q33 affecting the FGF14 and ITGBL1 genes, which may thus be considered a contiguous gene deletion syndrome.] |
|
spinocerebellar ataxia 30
|
DOID_0050979 |
[An autosomal dominant cerebellar ataxia that is characterized by slowly progressive gait abnormalities and dysarthria, has_material_basis_in mutation in the ODZ3 gene.] |
|
spinocerebellar ataxia 29
|
DOID_0050978 |
[An autosomal dominant cerebellar ataxia that is characterized by progressive ataxia, intellectual disability, dysarthria and ophthalmoplegia, and has_material_basis_in mutation in the ITPR1 gene.] |
|
spinocerebellar ataxia 10
|
DOID_0050960 |
[An autosomal dominant cerebellar ataxia that is characterized by gait ataxia, upper-limb ataxia, dysarthria and dysphagia, has_material_basis_in mutation in the ATXN10 gene.] |
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pleural cavity
|
UBERON_0002402 |
|
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mediastinum
|
UBERON_0003728 |
|
|
spinocerebellar ataxia 18
|
DOID_0050969 |
[An autosomal dominant cerebellar ataxia that is characterized by cerebellar ataxia and sensory neuropathy, has_material_basis_in mutation on chromosome 7q22-q23.] |
|
spinocerebellar ataxia 12
|
DOID_0050962 |
[An autosomal dominant cerebellar ataxia that is characterized by minor ataxia and intention tremor, has_material_basis_in CAG expansion of the PPP2R2B gene.] |
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spinocerebellar ataxia 11
|
DOID_0050961 |
[An autosomal dominant cerebellar ataxia that is characterized by ataxia, nystagmus, pyramidal abnormalities and peripheral neuropathy, has_material_basis_in mutation in the TTBK2 gene.] |
|
spinocerebellar ataxia 14
|
DOID_0050964 |
[An autosomal dominant cerebellar ataxia that is characterized by progressive ataxia, dysarthria and dysphagia, has_material_basis_in mutation in the PRKCG gene.] |
|
spinocerebellar ataxia 13
|
DOID_0050963 |
[An autosomal dominant cerebellar ataxia that is characterized by developmental delay, ataxia, myoclinic jerks, dysarthria, dysphagia and seizure, and has_material_basis_in mutation in the KCNC3 gene.] |
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obsolete spinocerebellar ataxia type 16
|
DOID_0050966 |
[An autosomal recessive cerebellar ataxia that is characterized by truncal and limb ataxia, dysarthria, nystagmus, peripheral neuropathy and limb spasticity, has_material_basis_in mutation in the STUB1 gene.] |
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spinocerebellar ataxia 15
|
DOID_0050965 |
[An autosomal dominant cerebellar ataxia that is characterized by progressive ataxia, nystagmus, dysarthria and dysphagia, has_material_basis_in mutation in the ITPR1 gene.] |