|
posterior polymorphous corneal dystrophy 3
|
DOID_0110857 |
[A posterior polymorphous corneal dystrophy that has_material_basis_in heterozygous mutation in the ZEB1 gene on chromosome 10p11.22.] |
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obsolete Burkitt's tumor or lymphoma involving lymph nodes of inguinal region and lower limb
|
DOID_9037 |
|
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lambda 5 deficiency
|
DOID_0060024 |
[A B cell deficiency that has_material_basis_in mutations in the IGLL1 gene. Lambda 5 mutations can cause a block in B cell development at the transition between the pro-B cell and the pre-B cell stage.] |
|
immunodeficiency with hyper IgM type 3
|
DOID_0060023 |
[A hyper IgM syndrome that has_material_basis_in mutation in the TNFRSF5 gene, resulting in type 3 hyper-IgM immunodeficiency that is characterized by an inability of B cells to undergo isotype switching, an inability to mount an antibody-specific immune response, and a lack of germinal center formation.] |
|
CD40 ligand deficiency
|
DOID_0060022 |
[A combined T cell and B cell immunodeficiency that is a X-linked immunodeficiency with hyperimmunoglobulin M (XHIM) affecting isotype switching and is caused by the absence of CD40 ligand which is normally expressed on activated CD4+ T cells. Individuals with this mutation are unable to switch from IgM to IgG, IgA and IgE.] |
|
DNA ligase IV deficiency
|
DOID_0060021 |
[A combined T cell and B cell immunodeficiency that has_material_basis_in a mutation in the LIG4 gene, a DNA ligase, encoding a protein essential for V(D)J recombination and DNA double-strand break (DSB) repair through nonhomologous end joining (NHEJ). Patients present with immunodeficiency and developmental and growth delay.] |
|
reticular dysgenesis
|
DOID_0060020 |
[A severe combined immunodeficiency that is the most severe form of SCID and has_material_basis_in mutations in the gene encoding mitochondrial adenylate kinase 2. It is characterized by congenital agranulocytosis, lymphopenia, and lymphoid and thymic hypoplasia with absent cellular and humoral immunity functions.] |
|
jaw-winking syndrome
|
DOID_560 |
[A cranial nerve disease characterized by unilateral congenital ptosis and rapid exaggerated elevation of the ptotic lid on moving of the lower jaw.] |
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holoprosencephaly 4
|
DOID_0110880 |
[A holoprosencephaly that has_material_basis_in heterozygous mutation in the TGIF gene on chromosome 18p11.] |
|
inflammatory bowel disease 12
|
DOID_0110887 |
[An inflammatory bowel disease that has_material_basis_in variation in the chromosome region 3p21.3.] |
|
inflammatory bowel disease 18
|
DOID_0110888 |
[An inflammatory bowel disease that has_material_basis_in variation in the chromosome region 5p13.1.] |
|
inflammatory bowel disease 10
|
DOID_0110885 |
[An inflammatory bowel disease that has_material_basis_in variation in the ATG16L1 gene on chromosome 2q37.] |
|
inflammatory bowel disease 9
|
DOID_0110886 |
[An inflammatory bowel disease that has_material_basis_in variation in the chromosome region 3p26.] |
|
acute pyelonephritis
|
DOID_559 |
|
|
inflammatory bowel disease 17
|
DOID_0110883 |
[An inflammatory bowel disease that has_material_basis_in variation in the IL23R gene on chromosome 1p31.3.] |
|
obsolete Burkitt's tumor or lymphoma involving lymph nodes of multiple sites
|
DOID_9010 |
|
|
inflammatory bowel disease 23
|
DOID_0110884 |
[An inflammatory bowel disease that has_material_basis_in variation in the chromosome region 1q32.1.] |
|
holoprosencephaly 1
|
DOID_0110881 |
[A holoprosencephaly that has_material_basis_in variation in the chromosome region 21q22.3.] |
|
inflammatory bowel disease 7
|
DOID_0110882 |
[An inflammatory bowel disease that has_material_basis_in variation in the chromosome region 1p36.] |
|
obsolete Hodgkin's lymphoma, nodular sclerosis, involving spleen
|
DOID_9001 |
|