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congenital nongoitrous hypothyroidism 2
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DOID_0070124 |
[A congenital hypothyroidism that has_material_basis_in heterozygous mutation in the PAX8 gene on chromosome 2q13.] |
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hypomyelinating leukodystrophy 7
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DOID_0060794 |
[A hypomyelinating leukodystrophy characterized by autosomal recessive inheritance of hildhood onset of progressive motor decline manifest as spasticity, ataxia, tremor, and cerebellar signs, as well as mild cognitive regression that has_material_basis_in homozygous or compound heterozygous mutation in the POLR3A gene on chromosome 10q22.] |
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Spinareoviridae
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NCBITaxon_2946187 |
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Orthoherpesviridae
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NCBITaxon_3044472 |
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Herpesvirales
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NCBITaxon_548681 |
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autosomal recessive cutis laxa type IIIA
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DOID_0070132 |
[A autosomal recessive cutis laxa type III that has_material_basis_in homozygous mutation in the ALDH18A1 gene on chromosome 10q24.] |
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ectrodactyly, ectodermal dysplasia, and cleft lip-palate syndrome 1
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DOID_0060784 |
[An EEC syndrome characterized by autosomal dominant inheritance that has_material_basis_in variation in the chromosome region 7q11.2-q21.3.] |
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EEC syndrome
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DOID_0060782 |
[A syndrome characterized by ectrodactyly, ectodermal dysplasia, and orofacial clefts (cleft lip-palate).] |
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autosomal recessive cutis laxa type IB
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DOID_0070133 |
[An autosomal recessive cutis laxa type I characterized by disturbed elastic fiber formation resulting in severe systemic connective tissue abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in the EFEMP2 gene on chromosome 11q13.] |
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typical adult-onset autosomal dominant demyelinating leukodystrophy
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DOID_0060785 |
[An adult onset demyelinating leukodystrophy characterized by autonomic abnormalities, pyramidal and cerebellar dysfunction, and symmetric demyelination of the CNS, presenting in the fourth or fifth decade of life, and that has_material_basis_in a heterozygous tandem genomic duplication on chromosome 5q23 that results in an extra copy of the lamin B1 gene (LMNB1), but also alters regulatory sequences that affect expression of other genes.] |
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adult onset demyelinating leukodystrophy
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DOID_0051015 |
[A leukodystrophy that is characterized by central nervous system demyelination, leading to autonomic dysfunction, ataxia and mild cognitive impairment.] |
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autosomal dominant cutis laxa 1
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DOID_0070130 |
[An autosomal dominant cutis laxa that has_material_basis_in heterozygous mutations in the ELN gene on chromosome 7q11.] |
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leukodystrophy
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DOID_10579 |
[A cerebral degeneration characterized by dysfunction of the white matter of the brain.] |
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autosomal dominant cutis laxa 3
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DOID_0070131 |
[An autosomal dominant cutis laxa characterized by thin skin with visible veins and wrinkles, cataract or corneal clouding, clenched fingers, pre- and postnatal growth retardation, moderate intellectual disability, and a combination of muscle hypotonia with brisk muscle reflexes that has_material_basis_in heterozygous mutation in the ALDH18A1 gene on chromosome 10q24.] |
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hypomyelinating leukodystrophy 2
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DOID_0060787 |
[A hypomyelinating leukodystrophy characterized by autosomal recessive inheritance of nystagmus, impaired motor development, ataxia, choreoathetotic movements, dysarthria, and progressive spasticity that has_material_basis_in homozygous or compound heterozygous mutation in the GJC2 gene on chromosome 1q42.] |
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hypomyelinating leukodystrophy 10
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DOID_0060788 |
[A hypomyelinating leukodystrophy characterized by autosomal recessive inheritance of progressive postnatal microcephaly, severely delayed psychomotor development and hypomyelination that has_material_basis_in homozygous mutation in the PYCR2 gene on chromosome 1q42.] |
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hypomyelinating leukodystrophy 4
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DOID_0060789 |
[A hypomyelinating leukodystrophy characterized by autosomal recessive inheritance of hypotonia, nystagmus, psychomotor developmental delay, and severe hypomyelinating leukoencephalopathy that has_material_basis_in homozygous mutation in the HSPD1 gene on chromosome 2q33.] |
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Lentivirus humimdef2
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NCBITaxon_3418651 |
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Lentivirus humimdef1
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NCBITaxon_3418650 |
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autosomal recessive cutis laxa type IIIB
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DOID_0070138 |
[An autosomal recessive cutis laxa type III that has_material_basis_in homozygous or compound heterozygous mutation in the PYCR1 gene on chromosome 17q25.] |