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Wolfram syndrome 2
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DOID_0110630 |
[An autosomal recessive neurodegenerative disorder characterized by diabetes mellitus, high frequency sensorineural hearing loss, optic atrophy or neuropathy, and defective platelet aggregation resulting in peptic ulcer bleeding. It has_material_basis_in autosomal recessive inheritance of homozygous or compound heterozygous mutation in the CISD2 gene on chromosome 4q24.] |
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obsolete arthrogryposis due to muscular dystrophy
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DOID_0110631 |
[A congenital muscular dystrophy characterized by nonprogressive myopathy resulting in an arthrogryposis syndrome.] |
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Toxocara
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NCBITaxon_6264 |
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immunodeficiency 15A
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DOID_0111960 |
[A combined T cell and B cell immunodeficiency characterized by immune dysregulation, combined T and B cell deficiency, inflammation, and epithelial defects that has_material_basis_in heterozygous missense mutation in the IKBKB gene on chromosome 8p11.21.] |
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autosomal recessive limb-girdle muscular dystrophy type 28
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DOID_0061130 |
[An autosomal recessive limb-girdle muscular dystrophy characterized by progressive muscle weakness affecting the proximal and axial muscles of the upper and lower limbs that has_material_basis_in homozygous or compound heterozygous mutation in the HMGCR gene on chromosome 5q13.] |
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end stage renal disease
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DOID_783 |
[A chronic kidney disease is characterized by non-functioning kidneys, as the final stage in chronic kidney disease.] |
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autosomal recessive limb-girdle muscular dystrophy type 26
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DOID_0061131 |
[An autosomal recessive limb-girdle muscular dystrophy characterized by adult-onset weakness that primarily affects the proximal muscles of the lower limbs that has_material_basis_in homozygous mutation in the POPDC3 gene on chromosome 6q21.] |
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renal infectious disease
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DOID_782 |
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immunodeficiency 39
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DOID_0111969 |
[A primary immunodeficiency disease characterized by impaired interferon I and III production in response to influenza virus infection that has_material_basis_in homozygous or compond heterozygous mutation in the IRF7 gene on chromosome 11p15.5.] |
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obsolete congenital muscular dystrophy merosin-positive
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DOID_0110638 |
[A congenital muscular dystrophy characterized by autosomal recessive inheritance of generalized muscle weakness and hypotonia without arthrogryposis or central nervous system involvement that has_material_basis_in mutation in the chromosome region 4p16.3.] |
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autosomal recessive limb-girdle muscular dystrophy type 23
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DOID_0061132 |
[An autosomal recessive limb-girdle muscular dystrophy characterized by slowly progressive proximal muscle weakness primarily affecting the lower limbs and resulting in gait difficulties that has_material_basis_in y homozygous or compound heterozygous mutation in the LAMA2 gene on chromosome 6q22.] |
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obsolete hypotony of eye associated with another ocular disorder
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DOID_789 |
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congenital muscular dystrophy due to integrin alpha-7 deficiency
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DOID_0110639 |
[A congenital muscular dystrophy characterized by autosomal recessive inheritance that has_material_basis_in compound heterozygous mutation in the ITGA7 gene on chromosome 12q13.] |
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autosomal recessive limb-girdle muscular dystrophy type 27
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DOID_0061133 |
[An autosomal recessive limb-girdle muscular dystrophy characterized by progressive muscle weakness primarily affecting the lower limbs and resulting in walking difficulty or loss of ambulation that has_material_basis_in homozygous or compound heterozygous mutation in the JAG2 gene on chromosome 14q32.] |
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immunodeficiency 54
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DOID_0111967 |
[A NK cell deficiency characterized by severe intra- and extrauterine growth retardation, microcephaly, decreased numbers of CD56(dim) natural killer cells, adrenal insufficiency, and recurrent viral infections that has_material_basis_in homozygous or compound heterozygous mutation in the MCM4 gene on chromosome 8q11.21.] |
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congenital merosin-deficient muscular dystrophy 1A
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DOID_0110636 |
[A congenital muscular dystrophy characterized by autosomal recessive inheritance of muscle weakness that is apparent at birth or in the first 6 months of life and frequent development of periventricular white matter abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in the LAMA2 gene on chromosome 6q22.] |
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autosomal recessive limb-girdle muscular dystrophy type 29
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DOID_0061134 |
[An autosomal recessive limb-girdle muscular dystrophy characterized by onset of muscle weakness predominantly affecting the proximal lower limbs, although upper limb involvement also occurs that has_material_basis_in homozygous or compound heterozygous mutation in the SNUPN gene on chromosome 15q24.] |
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muscular dystrophy-dystroglycanopathy type B6
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DOID_0110637 |
[A congenital muscular dystrophy characterized by autosomal recessive inheritance of muscular dystrophy with mental retardation and structural brain abnormalities that has_material_basis_in homozygous or compound heterozygous mutation in the LARGE gene on chromosome 22q12.] |
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immunodeficiency 41
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DOID_0111968 |
[A combined immunodeficiency characterized by a defect in T cell regulation with proliferation of CD8+ T cells, impaired antibody specific responses, and elevated cytokines resulting in recurrent viral, fungal, and bacterial infections, lymphadenopathy, and variable autoimmune features that has_material_basis_in homozygous or compound heterozygous mutation in the IL2RA gene on chromosome 10p15.1.] |
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infantile hypercalcemia 2
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DOID_0061135 |
[A hypercalcemia that has_material_basis_in homozygous or compound heterozygous mutation in the SLC34A1 gene on chromosome 5q35.] |