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glutaric acidemia I
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DOID_0111254 |
[An organic acidemia characterized by impaired lysine, hydroxylysine, and tryptophan metabolism, increased urinary excretion of glutaric acid, and accumulation of 3-hydroxyglutaric and glutaric acid, resulting in striatal injury and a severe dystonic dyskinetic movement disorder that has_material_basis_in homozygous or compound heterozygous mutation in the GCDH gene on chromosome 19p13.] |
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Parkinson's disease 21
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DOID_0111251 |
[A late onset Parkinson's disease characterized by autosomal dominant inheritance and mean age of onset at 67 years.] |
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bone of free limb or fin
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UBERON_0004375 |
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vestibular schwannomatosis
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DOID_0111252 |
[A schwannomatosis characterized by bilateral vestibular schwannomas or a combination of unilateral vestibular schwannomas, non-vestibular schwannomas, meningiomas, ependymomas, and specific eye abnormalities that has_material_basis_in heterozygous mutation in the NF2 gene on chromosome 22q12.2. Eye abnormalities include juvenile subcapsular or cortical cataract, epiretinal membrane in a person less than 40 years old, and retinal hamartoma. This disease has been revised by international consensus. It was previously referred to as neurofibromatosis 2.] |
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Parkinson's disease 3
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DOID_0111250 |
[A late onset Parkinson's disease characterized by mean age of onset of 59 years and that has_material_basis_in mutation in a locus in the 2p13 chromosome region.] |
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ester
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CHEBI_35701 |
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postaxial acrofacial dysostosis
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DOID_0111259 |
[A syndrome characterized by severe micrognathia, cleft lip and/or palate, hypoplasia or aplasia of the postaxial elements of the limbs, coloboma of the eyelids, cup-shaped ears, and supernumerary nipples that has_material_basis_in homozygous or compound heterozygous mutation in DHODH on 16q22.2.] |
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gamma-glutamyl transpeptidase deficiency
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DOID_0111257 |
[An amino acid metabolic disorder characterized by accumulation of glutathione in the plasma and urine that has_material_basis_in homozygous or compound heterozygous mutation in GGT1 on 22q11.23.] |
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pentosuria
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DOID_0111258 |
[An amino acid metabolic disorder characterized by excretion of excess pentose L-xylulose (1-4 g/day) in the urine that has_material_basis_in homozygous or compound heterozygous mutation in DCXR on 17q25.3.] |
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fin bone
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UBERON_0004376 |
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McKusick-Kaufman syndrome
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DOID_0111255 |
[A syndrome characterized by neonatal onset of genitourinary malformations, especially hydrometrocolpos, polydactyly, and, more rarely, heart or gastrointestinal malformations that has_material_basis_in homozygous or compound heterozygous mutation in MKKS on 20p12.2.] |
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hyperferritinemia-cataract syndrome
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DOID_0111256 |
[A syndrome characterized by elevated circulating levels of ferritin without iron overload and early onset cataracts that has_material_basis_in heterozygous mutation in the iron responsive element in the 5-prime noncoding region of FTL on 19q13.33.] |
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beta-lactam
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CHEBI_35627 |
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congenital muscular dystrophy-dystroglycanopathy type A6
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DOID_0111242 |
[A congenital muscular dystrophy-dystroglycanopathy type A that has_material_basis_in homozygous or compound heterozygous mutation in LARGE on 22q12.3.] |
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acromicric dysplasia
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DOID_0111243 |
[An osteochondrodysplasia characterized by autosomal dominant inheritance of severe short stature, short hands and feet, joint limitations, mild facial anomalies, skin thickening, and bone abnormalities including delayed bone age, cone-shaped epiphyses, shortened long tubular bones, and ovoid vertebral bodies that has_material_basis_in heterozygous mutation in FBN1 on 15q21.1.] |
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Ancylostomatinae
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NCBITaxon_53469 |
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congenital muscular dystrophy-dystroglycanopathy type A2
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DOID_0111240 |
[A congenital muscular dystrophy-dystroglycanopathy type A that has_material_basis_in homozygous or compound heterozygous mutation in POMT2 on 14q24.3.] |
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congenital muscular dystrophy-dystroglycanopathy type A5
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DOID_0111241 |
[A congenital muscular dystrophy-dystroglycanopathy type A that has_material_basis_in homozygous or compound heterozygous mutation in FKRP on 19q13.32.] |
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lead
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CHEBI_25016 |
[A chemical driver that is composed of lead, which is found primarily in old paint, old paint dust, contaminated soil or contaminated drinking water.] |
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cerebrocostomandibular syndrome
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DOID_0111248 |
[A syndrome characterized by severe micrognathia, posterior rib and palate defects, and often intellectual disability that has_material_basis_in heterozygous mutation in SNRPB on 20p13.] |