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autosomal dominant isolated macrothrombocytopenia 1
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DOID_0090102 |
[A thrombocytopenia that is characterized by macrothrombocytopenia with normal platelet aggregation and has_material_basis_in autosomal dominant inheritance of mutation in the tubulin beta-1 (TUBB1) gene on chromosome 20q13.3.] |
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ocular albinism with sensorineural deafness
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DOID_0090100 |
[An ocular albinism that is characterized by deafness and vestibular dysfunction and has_material_basis_in digenic inheritance of a mutation in the transcription factor gene MITF on chromosome 3p13 and in the tyrosinase TYR gene on chromosome 11q14.3 that MITF regulates.] |
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ocular albinism 1
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DOID_0050633 |
[An eye disease that is characterized by reduced pigmentation of the iris and the resulting impairment of visual acuity without significantly affecting the color of skin or hair and has_material_basis_in mutation in the GPR143 gene that encodes segments of the melanosomes that stores melanin.] |
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autosomal recessive hypercholesterolemia
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DOID_0090105 |
[A familial hypercholesterolemia that is characterized by very high levels of low-density lipoprotein (LDL) cholesterol (usually above 400 mg/dl) and increased risk of premature atherosclerotic cardiovascular disease, and has_material_basis_in autosomal recessive homozygous mutation in the low density lipoprotein receptor adaptor protein 1 gene (LDLRAP1) on chromosome 1p36.] |
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familial hypercholesterolemia
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DOID_13810 |
[A familial hyperlipidemia characterized by very high levels of low-density lipoprotein (LDL) and early cardiovascular disease.] |
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acne
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DOID_6543 |
[A sebaceous gland disease characterized by areas of blackheads, whiteheads, pimples, greasy skin, and possibly scarring.] |
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BH4-deficient hyperphenylalaninemia A
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DOID_0090106 |
[A tetrahydrobiopterin (BH4)-deficient hyperphenylalaninemia that is characterized by hyperphenylalaninemia, depletion of the neurotransmitters dopamine and serotonin, and progressive cognitive and motor deficits that has_material_basis_in autosomal recessive inheritance of mutation in the gene encoding 6-pyruvoyl-tetrahydropterin synthase (PTS) on chromosome 11q23.1.] |
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obsolete transient organic mental disorder
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DOID_6540 |
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congenital disorder of glycosylation
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DOID_5212 |
[A carbohydrate metabolic disorder that involves deficient or defective glycosylation of a variety of tissue proteins and/or lipids.] |
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Huntington's disease-like 1
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DOID_0090103 |
[A prion disease that is characterized by a phenocopy of Huntington disease (unwanted choreatic movements, behavioral and psychiatric disturbances and dementia) that has_material_basis_in autosomal dominant inheritance of 8 extra octapeptide repeats in the prion protein (PRNP) gene on chromosome 20p13.] |
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Huntington's disease-like 2
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DOID_0090104 |
[A neurodegenerative disease characterized by involuntary movements and abnormalities of voluntary movements, psychiatric symptoms, weight loss, and dementia with onset in the fourth decade and death about 20 years after disease onset, and has_material_basis_in autosomal dominant inheritance of heterozygous expansion of a CAG/CTG repeat in the junctophilin-3 gene (JPH3) on chromosome 16q24.] |
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obsolete secondary cardiac lymphoma
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DOID_6546 |
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demyelinating polyneuropathy
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DOID_5214 |
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autosomal dominant hypocalcemia
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DOID_0090109 |
[A metal metabolism disorder characterized by autosomal dominant inheritance of variable degrees of hypocalcemia with normal to low levels of parathyroid hormone.] |
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chronic inflammatory demyelinating polyradiculoneuropathy
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DOID_5213 |
[An autoimmune disease of peripheral nervous system that is characterized by inflammation of nerve roots and peripheral nerves and destruction of the fatty protective covering (myelin sheath) over the nerves. This affects how fast the nerve signals are transmitted and leads to loss of nerve fibers.] |
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heart lymphoma
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DOID_6547 |
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uterine corpus atypical polypoid adenomyoma
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DOID_7878 |
[An atypical polypoid adenomyoma that is located_in the uterine corpus.] |
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Treacher Collins syndrome 2
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DOID_0080790 |
[A Treacher Collins syndrome that has_material_basis_in heterozygous mutation in the POLR1D gene on chromosome 13q12.] |
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obsolete atypical meningioma
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DOID_6544 |
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adult xanthogranuloma
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DOID_7875 |
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