This is just here as a test because I lose it
Term information
alternative term
P-gp inhibition
P-glycoprotein (P-gp) inhibition assay
P-glycoprotein inhibition assay
MDR1 inhibition
multi-drug resistance 1 inhibition
ABCB1 inhibition
definition
The P-gp inhibition assay is a functional in vitro study that quantifies the concentration-dependent disruption of the active efflux function of the human P-glycoprotein (P-gp or ABCB1) transporter. This ATP-driven efflux activity, which normally pushes drug substrates out of cells, is measured as a decrease in the P-gp-mediated transport of a probe substrate (like digoxin) when the test compound is present in a polarized cell monolayer or an inside-out membrane vesicle system.
Term relations
Subclass of:
- efflux transporter inhibition assay
- has assay format some cell based format
- has substrate some taurocholate
- has endpoint some IC50
- has cell line some HEK293
- has experimental setting only in vitro
- has detection method some scintillation counting
- has bioassay type some functional
- has endpoint some Ki
- has organism only Homo sapiens
- has bioassay type some ADME