This is just here as a test because I lose it
Term information
definition
The MRP2 inhibition assay is a functional in vitro study that quantifies a compound's ability to block the active efflux function of the human Multidrug Resistance-associated Protein 2 (MRP2 or ABCC2) transporter. It typically uses inside-out membrane vesicles (IOVs) prepared from MRP2-expressing cells, which allows the transporter's ATP-dependent efflux activity to be measured as an easily quantifiable substrate accumulation into the vesicle.
Term relations
Subclass of:
- efflux transporter inhibition assay
- has assay format some cell based format
- has endpoint some IC50
- has cell line some HEK293
- has experimental setting only in vitro
- has detection method some liquid chromatography-tandem mass spectrometry
- has detection method some scintillation counting
- has assay design method some liquid chromatography
- has bioassay type some functional
- has endpoint some Ki
- has organism some Homo sapiens
- has bioassay type some ADME