This is just here as a test because I lose it
Term information
alternative term
RRCK permeability
Ralph Russ Canine Kidney (RRCK) assay
Ralph Russ Canine Kidney assay
RRCK assay
definition
The RRCK permeability assay is a proprietary in vitro assay that uses a specific subclone of the MDCK canine kidney cell line to determine a compound's passive membrane permeability coefficient (Papp) across a cellular monolayer. The RRCK cell line is characterized by low or minimal expression of endogenous efflux transporters, which reduces interference from active transport mechanisms, thus isolating the passive diffusion component of drug permeation.
Term relations
Subclass of:
- permeability assay
- has assay format some cell based format
- has experimental setting only in vitro
- has bioassay type only functional
- has bioassay type only ADME