This is just here as a test because I lose it
Term information
alternative term
metabolic stability in liver microsomes
liver microsomal stability
microsome stability assay
liver microsome stability
microsome stability
microsomal stability
definition
A common in vitro ADME assay that tests the stability of compounds when incubated with liver microsomes (subcellular fractions which contain membrane-bound drug-metabolizing enzymes). Assay is used to measure in vitro intrinsic clearance or to identify metabolites formed. Typically liver microsomes from one or more mammalian species (mouse, rat, dog, monkey, human) are analyzed to understand differences in metabolism. Can be reported as % recovery after a set time (single timepoint), or as half-life (multiple timepoints).
Term relations
Subclass of:
- metabolic stability assay
- has assay format some microsome format
- has detection method some quantitative reverse transcription PCR
- has endpoint some T1/2(in vitro)
- has endpoint some CLint
- has endpoint some vmax
- has detection method some liquid chromatography-tandem mass spectrometry
- has experimental setting only in vitro
- has organism some Homo sapiens
- has endpoint some km
- has organism only Homo sapiens
- has bioassay type only ADME